Detalhe da pesquisa
1.
Inferring a complete genotype-phenotype map from a small number of measured phenotypes.
PLoS Comput Biol
; 16(9): e1008243, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32991585
2.
Biochemical characterization and chemical inhibition of PfATP4-associated Na+-ATPase activity in Plasmodium falciparum membranes.
J Biol Chem
; 293(34): 13327-13337, 2018 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29986883
3.
Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter.
Proc Natl Acad Sci U S A
; 111(17): E1759-67, 2014 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24728833
4.
Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.
J Infect Dis
; 213(5): 800-10, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26503982
5.
Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites.
J Biol Chem
; 289(52): 36336-51, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25378409
6.
Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.
Cell Mol Life Sci
; 69(12): 1967-95, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22286067
7.
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.
Nat Commun
; 14(1): 1455, 2023 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36927839
8.
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.
Cell Chem Biol
; 29(2): 191-201.e8, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34348113
9.
Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity.
Eur J Med Chem
; 215: 113227, 2021 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33601312
10.
The natural function of the malaria parasite's chloroquine resistance transporter.
Nat Commun
; 11(1): 3922, 2020 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32764664
11.
Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT.
ACS Med Chem Lett
; 5(5): 576-81, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900883
12.
1H-NMR metabolite profiles of different strains of Plasmodium falciparum.
Biosci Rep
; 34(6): e00150, 2014 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25405893
13.
Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum.
ACS Chem Biol
; 9(3): 722-30, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24369685
14.
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.
J Med Chem
; 55(15): 6948-67, 2012 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22783984
15.
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
J Med Chem
; 55(23): 10387-404, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23145816
16.
Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).
J Med Chem
; 54(19): 6956-68, 2011 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21875063
17.
Functional characteristics of the malaria parasite's "chloroquine resistance transporter": implications for chemotherapy.
Virulence
; 1(4): 304-8, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-21178460